Innovation in biotechnology, specifically genetic engineering, molecular markers and molecular diagnostics, is a key enabler to development across health, agriculture and industrial sectors tackling some of societies biggest problems. In the global South, the supply chain that supports such innovation is broken leaving researchers paying more, waiting longer and lacking the support to do the science needed to grow bioeconomies and solve local challenges. Beneficial Bio is a network of locally-owned biologist-led social enterprises across Africa, Asia and Latin America. With the initial support from our support team in Cambridge, U.K., we manufacture high-quality, low-cost and cold-chain independent synthetic biology reagents and enzymes to supply to local researchers with the toolkits for biotechnology innovation. Our pilot with the Mboa Lab in Yaoundé, Cameroon has provided infrastructure and capacity to support local research and bioeconomies through application of open science.